![]() ![]() Placebo (IV Q3W for one year or maximum 18 doses). KEYTRUDA (200 mg intravenously every three weeks for one year or maximum 18 doses) or The study enrolled 1,177 patients who were randomly assigned (1:1) to receive either: The secondary endpoints include OS and lung cancer-specific survival (the time from randomization to date of death due to lung cancer specifically). DFS is calculated as the time from randomization to the date of disease recurrence, occurrence of second lung cancer primary, occurrence of second malignancy, or death from any cause, whichever occurs first. The dual primary endpoints are DFS in the overall population and in patients whose tumors express PD-L1 (TPS ≥50%). ![]() KEYNOTE-091, also known as EORTC-1416-LCG/ETOP-8-15 – PEARLS, is a randomized, Phase 3 trial (, NCT02504372) sponsored by Merck and conducted in collaboration with EORTC and ETOP evaluating KEYTRUDA compared to placebo for the adjuvant treatment of patients with stage IB-IIIA NSCLC following surgical resection (lobectomy or pneumonectomy) with or without adjuvant chemotherapy. The results from KEYNOTE-091 are a first for KEYTRUDA in the adjuvant treatment setting in patients with stage IB-IIIA NSCLC.Ībout KEYNOTE-091/EORTC-1416-LCG – PEARLS Merck has an extensive clinical development program in lung cancer and is advancing multiple registration-enabling studies with KEYTRUDA in combination with other treatments and as monotherapy for the treatment of lung cancer. By moving KEYTRUDA into earlier stages of non-small cell lung cancer, we may be able to reduce the risk of disease recurrence after surgery for patients with stage IB-IIIA non-small cell lung cancer.” “The goal of adjuvant treatment is to lower the risk of cancer returning after surgery. Luis Paz-Ares, chair of the medical oncology department, Hospital Universitario Doce de Octubre, Madrid, Spain and co-principal investigator. “Globally, lung cancer is the leading cause of cancer death and it remains critically important to detect and treat lung cancer early,” said Dr. “Data from KEYNOTE-091 suggest adjuvant KEYTRUDA reduced the risk of disease recurrence or death after surgery in the overall population of patients with stage IB-IIIA non-small cell lung cancer.” “Surgery is widely considered the first and most important intervention for most patients with early-stage non-small cell lung cancer however, an estimated 43% of those who undergo surgery will see their disease return,” said Professor Mary O’Brien, The Royal Marsden, NHS Foundation Trust, and Imperial College, London, UK and co-principal investigator. We thank the patients, investigators and our partners at EORTC and ETOP for their important contributions to this study and look forward to sharing these results with the medical community as soon as possible.” “We are encouraged by these results supporting the potential role of KEYTRUDA in stage IB-IIIA non-small cell lung cancer. Roy Baynes, senior vice president and head of global clinical development, chief medical officer, Merck Research Laboratories. “KEYTRUDA has become foundational in the treatment of metastatic non-small cell lung cancer and we continue to advance research to explore its potential to help fight cancer earlier,” said Dr. Results will be presented at an upcoming medical meeting and will be submitted to regulatory authorities. The safety profile of KEYTRUDA in this study was consistent with that observed in previously reported studies. The trial will continue to analyze DFS in patients whose tumors express high levels of PD-L1 (TPS ≥50%) and evaluate overall survival (OS), a key secondary endpoint. Based on an interim analysis review conducted by an independent Data Monitoring Committee, adjuvant treatment with KEYTRUDA resulted in a statistically significant and clinically meaningful improvement in DFS compared with placebo in the all-comer population of patients with stage IB-IIIA NSCLC.Īt the interim analysis, there was also an improvement in DFS for patients whose tumors express PD-L1 (tumor proportion score ≥50%) treated with KEYTRUDA compared to placebo however, this dual primary endpoint did not meet statistical significance per the pre-specified statistical plan. Merck (NYSE: MRK), known as MSD outside the United States and Canada, the European Organisation for Research and Treatment of Cancer (EORTC) and the European Thoracic Oncology Platform (ETOP) today announced that the Phase 3 KEYNOTE-091 trial, also known as EORTC-1416-LCG/ETOP-8-15 – PEARLS, investigating KEYTRUDA, Merck’s anti-PD-1 therapy, met one of its dual primary endpoints of disease-free survival (DFS) for the adjuvant treatment of patients with stage IB-IIIA non-small cell lung cancer (NSCLC) following surgical resection regardless of PD-L1 expression. First Positive Study for KEYTRUDA in Adjuvant Stage IB-IIIA NSCLC
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Many studies have been conducted on thyme species to identify their chemical composition. Figure 1 represents a botanical sketch of thyme. Finally, thyme can be propagated from seeds, cuttings or by layering. ![]() vulgaris is most affected by root rot disease. It has no invasive potential and can live for a maximum of 25 years. It does not need a lot of water but requires full sunlight. vulgaris grows in groups on calcareous rocks. It lives in loamy and sandy soils, having a neutral and alkaline pH. It can tolerate frost and drought and poor, salty environments. It takes 2 to 5 years to reach its maximum height. At maturity, it reaches 0.5 to 1 m in height and spreads over 0.5 to 1 m and sometimes 15 m on the ground as a green cover. ![]() Their blooming occurs during spring and summer. The flowers are of a cyme type, purple and white in color, bisexual and two-lipped with a hairy glandular calyx giving a pleasant scent. They mainly constitute the edible part for humans. They have an ovate shape, fine texture and a pleasant scent. ![]() The leaves are arranged as whorls around the stem, evergreen and simple. vulgaris is a perennial, evergreen subshrub with a generally upright, woody-based stem. The results showed that 124 plant species are still used by local communities in traditional medicine as a beneficial source for the treatment of different illnesses. As such, 53 native informants in 13 towns and villages surrounding Mount Hermon were asked about wild plants they use. A study was done in Lebanon by conducting semi-structured interviews in which ethno-pharmacological information was collected. Most well-known cooking methods of such plants are simply fried with onions or used in omelet preparations. In addition, several types of these plants are used in fresh salads. In Lebanon, WEPs are estimated at about 2600 species (12% of total species in the Mediterranean region) and are mainly consumed within rural areas for their health and medicinal qualities, either raw without any preliminary preparation, or as snacks, providing important sources of nutrients absent in modern high-fat, high-sugar snacks. The diversity of species in this region can rely on the ecological conditions, such as the convenient climate and the soil type. Specifically, in the Mediterranean region, there are an estimated 25,000 to 30,000 species of WEPs, many of which are endemic to the region. ![]() In addition, many use them as spices and for commercial purposes. For example, a study was done in the city of Bingol in Turkey and showed that most of the consumers in this area eat these plants in their raw form others use the flowers and branches for preparing herbal tea. In Africa, Latin America, and the subcontinent of India, many WEPs are cultivated and consumed. In North America, natives consume many WEPs daily they constitute a good example of the ethnographical use of these natural sources. China is characterized by having the oldest and biggest original centers for vegetables in the world, estimated to be around 213 families, 815 genera and 1822 species of plants. Among these 100, less than 20 species are used in food preparation. According to a recent estimate, more than 8000 plant species are distributed all over the world, from these only 100 provide the majority of the world’s food. Therefore, the trend towards implanting WEPs in food dishes and recipes nowadays, seems to have increased and become more popular than few years ago. Moreover, WEPs have been demonstrated to have an important role in providing plenty of nutritional requirements that are important for improving health, thereby contributing to reduce food insecurity and scarcity, famine, or conflict. In fact, as summarized by Shumsky and Colleagues, WEPs are characterized by being locally available and known traditionally through generations, less expensive, having high advantages for poor populations, available during stressful conditions such as drought or famine periods and finally, being able to resist climate change. Wild edible plants (WEPs) as defined by the food and agricultural organization (FAO) are “the plants that grow spontaneously in self -maintaining populations in natural or semi-natural ecosystems and can exit independently of direct human actions”. ![]() Update Thursday, April 9, 5:30 p.m.: Everyone has weighed in and now everyone’s mad. Usher is a King and always an inspiration so it was flattering to hear what him and Diplo did on climax. Of course media blows things out of proportion and takes things out of context. “Usher is a King and always an inspiration so it was flattering to hear what him and Diplo did on climax. ![]() “Of course media blows things out of proportion and takes things out of context,” he tweeted, as we’re left wondering what more context there could be to his verbatim claim that he thought “Climax” sounded like a Weeknd song. ![]() Update Thursday, April 9, 4:30 p.m.: It’s all come full circle and the Weeknd is back in the conversation he started. It was conceptual from the beginning.- diplo April 9, 2020 I remember I had the title of the song before I had the beat. I'm glad Ariel, Eric, and I all got together to make that epic song. Kind of like some relationships never make it to where you want them but for a moment it could feel like ecstasy.” … Wait, what were we talking about? Right: Diplo confirmed “Climax” is inspired by House of Balloons, the Weeknd’s publicist is killing this After Hours rollout, and Usher’s legend status remains untouched. “It was a song that always had a crescendo but never felt like it reached the peak. It was conceptual from the beginning,” he said. “I remember I had the title of the song before I had the beat. the idea of R&B having dark edges was what I wanted to bring to While Diplo credits the Weeknd with inspiration, he explained that “Climax” started way before the beat came together. “When I heard those early records they blew my mind - soulful in their silences, and a spacey iconic voice that felt uniquely internet. “The production on Climax lends itself to House of Balloons era he tweeted, confirming the Weeknd’s suspicion. Update Thursday, April 9, 3:45 p.m.: Sauntering into the discourse, presumably wearing a cowboy hat, “Climax” producer Diplo set the record straight on the Weeknd’s influence. This could be easily mended with a joint Instagram Live where we all sing Confessions. But what is the Weeknd gonna do? Drop a sick E5? Link a YouTube high note compilation? R&B beef just does not hit the same way as rap beef. Usher takes to his Instagram stories to sing his hit song “Climax” after The Weeknd claimed he copied his style in the song. Usher, who did not offer comment to Variety, instead captionlessly responded by singing “Climax” a cappella, high notes and all, on his Instagram Story Wednesday night. “I heard ‘Climax,’ that Usher song, and was like, ‘Holy f-, that’s a Weeknd song.’ It was very flattering, and I knew I was doing something right, but I also got angry.” Coming for an old head in a trade magazine, no less? His After Hours roll-out is full of surprises. “ House of Balloons literally changed the sound of pop music before my eyes,” he said. In a new interview with Variety, the Weeknd recalled one of the first moments he felt his music’s impact on the genre, throwing some shade in the process. This week, Hustlers extra Usher and the Weeknd have discreetly started beefing about an eight-year-old song - clearly quarantine has brought some stuff up. The world could be ending and soft boys would still figure out how to make it about them. ![]() Interact directly with Adobe Flash software.And when enabled by Acrobat Professional authors, you can now leverage robust commenting tools and actively participate in document reviews. You can use Adobe Reader 10 to read, interact with, and print Portable Document Format (PDF) files generated by such applications as the Adobe Acrobat family of products, Adobe Photoshop Album, and more.Īcrobat Reader 10 also lets you fill in and submit PDF forms online. Use Reader to view, search, digitally sign, verify, print, and collaborate on PDF files.Īdobe Reader 10 lets you view, print, and search PDF files on a variety of devices and operating systems with faster launch time and real-time zooming and panning. It is the only PDF file viewer that can open and interact with all PDF documents. However, you will only be able to access the program's free features, which are not enough to determine if the app is worth buying.Adobe Reader 10 software is the global standard for electronic document sharing. Registration asks for personal information, including your name, email address, company name, and phone number. However, for you to use all its features, you need to register. Users must note that the app is not free to use. Furthermore, it features commenting tools, shared reviews, and ConnectedPDF support that allows collaboration on documents and file change notifications. It also supports file sharing via cloud storage services, such as Google Drive, Box, OneDrive, and Dropbox. With DocuSign, SharePoint, NetDocuments, and iManage Worksite integration, the app makes it easy for users to share documents with anyone in their organization. More than robust document protection, Foxit Phantom PDF Standard allows easy file sharing and collaboration. The app also employs certificate encryption and digital signature validation to prevent others from reading confidential or private information that might reside in your documents. The app has a wide range of powerful document security tools that you can use to protect your files from online snoopers, including password protection. This program is primarily a PDF editor, but the app is also known for its extensive document protection features. As with other PDF converters, you can also use this app to convert documents saved in other formats into PDF. ![]() ![]() With this, you can easily share content with other software. You can also use the app to create PDF documents directly from Office applications, such as Word, PowerPoint, and Excel.įoxit Phantom PDF Standard extends its capabilities by allowing users to convert PDFs to various formats, including DOC, text, and images. You can make a completely new one from multiple files, from a scanned document, or your clipboard. In addition to editing, the app also allows you to create a PDF document. Furthermore, the app has form design tools, including XFA form filling, allowing you to fill out forms sent digitally. The app also has a bookmark manager and a comprehensive search function, which allows you to locate any element within the PDF file. With this, you can mark any part of your file or add any notes and comments. Like other popular paid or free PDF tools, the program also comes with annotations and highlight capabilities. More than that, you can also modify the background, header, and footer of your PDF document. The app also allows users to insert images and other multimedia files on any page. Additionally, you can add pages from a file or scanned document to your file. You can extract, remove, and duplicate contents, as well as crop and rotate them. As noted, the app provides you with a wide selection of editing options so that you can modify every aspect of your PDF files. ![]() Because this was a time when good medical advice was just going "losing a world war? Have you tried doing speedballs about it?" It's even been suggested that Hitler's erratic behavior in the final months of the war was down to withdrawals after the Allies bombed German drug factories.īrazilian National Archives Curiously, when the Allies reached the bunker they found all the copper stripped out of the walls. After an assassination attempt in 1944, doctors also started giving Hitler regular cocaine injections. Morell preferred a cocktail of steroids and opiates, as well as large doses of oxycodone. Meanwhile, Hitler, who prided himself on his healthy lifestyle, was secretly completely dependent on a shady doctor named Theo Morell. Hermann Goering, in particular, was captured at the end of the war desperately dragging around a suitcase of 20,000 codeine pills, of which he popped 20 a day. The really surprising thing is that there were any drugs left for the army after the Nazi top brass got through with them. Which was supposed to be enough to last an entire patrol for weeks. So he just dumped out the entire bottle and swallowed all 30 pills. And taking them off would have slowed him down, plus made his fingers cold. Unfortunately, it proved impossible to get a lone pill out of the bottle with his clumsy winter mittens. Now, with his life on the line, he reached for the meth. Ironically, Koivunen had always strongly disapproved of these drugs, which was why he was considered trustworthy enough to carry the whole stash. The patrol had been equipped with a stockpile of methamphetamine pills to keep their energy up in the heat of battle. Luckily, the Finns had a secret weapon: Meth! His comrades encouraged him to press on, but the exhaustion soon became overpowering. Yet as the chase went on, Koivunen felt his energy starting to flag. The Finns had no choice but to simply try to outski the enemy. ![]() Koivunen tried to throw the Soviets off by planting mines behind the patrol, but the cunning Soviets simply skied around the mines, which he had admittedly been planting in full view of them. What followed was an epic ski chase across a frozen landscape. Knud Bergslien Unfortunately, Scandinavian uniforms aren't very aerodynamic. Soviet ski troops came shooting down a nearby hill, seeking to encircle the Finns, who grabbed their own skis and sought to escape. According to a short memoir he wrote in the ‘70s (helpfully translated into English here), Koivunen and his patrol had just settled down under some spruce trees to make a tactical cup of tea when gunfire erupted all around them. Among the scouts was a young soldier named Aimo Koivunen. Facing a major Soviet invasion, the Finns sent a long-range ski patrol through the winter snows of Lapland to scout things out. 6 Aimo Koivunen Was An Ordinary Soldier Until He Accidentally Guzzled Meth Like A Crank-Loving Cookie Monsterīack in 1944, Finland was allied with Nazi Germany, while trying to communicate through body language alone that they really weren't with those guys and would totally be willing to switch sides if given half the chance. And then one guy it didn't really bring anything out in, because he accidentally did enough speed to kill an orca and wound up scampering through the woods, biting the heads off small animals and staging ski-based drive-bys on the deeply confused Red Army. ![]() The inferno brought out the best in some and the worst in others. The Second World War was the most devastating conflict in history, a titanic struggle waged across five continents and costing countless lives. The level of UVA radiation protection exceeds the EU recommendation. ![]() Garshick, M.D., F.A.A.D., a board-certified dermatologist in New York. ¹ Meets the high standards set by Cosmetics Europe for protection against UVA and UVB radiation. Zinc oxide sunscreens are an especially great option for those with sensitive skin, says Marisa K. The transparent and non-greasy product absorbs quickly and is water-resistant.Įucerin Sun Oil Control Dry Touch Sunscreen with SPF30 is clinically and dermatologically proven to be suitable for sensitive skin, including acne-prone skin. Clinical and dermatological studies have demonstrated excellent tolerability on sensitive skin, including oily and acne-prone skin. ![]() UV rays are the main cause of sun-induced skin damage, but high-energy visible (HEVIS) light can also stimulate free radicals, which cause additional stress on the skin.Įucerin Sun Oil Control Dry Touch SPF30 is a spray-on sunscreen for the body that soothes and protects sensitive skin, including acne-prone skin.Īdvanced Spectral technology combines broad-spectrum and photostable UVA/UVB filters for high UV protection with Lycochalcone A to neutralize free radicals produced by UVA and HEVIS light.¹ Advanced Hydration Sunscreen Spray SPF 50. For sensitive skin, including acne-prone skin Eucerin Sun Spray Oil Control Transparent SPF 30 is a sunscreen spray for the body that soothes and protects sensitive skin including acne-prone skin. Whether you have aging skin, acne-prone skin, or dry skin, Eucerin Sun has a specific formulation that provides broad-spectrum sun protection for all skin tones while addressing your specific skin type. The words 'oil-free' and 'noncomedogenic' are allies when it comes to SPF for pimple-prone folks, which is precisely why Neutrogena 's Clear.Advanced Spectral Technology: protection against UVA/UVB radiation and HEVIS light.High protection against solar radiation Best for Acne-Prone Skin Supergoop Mineral Mattescreen Sunscreen SPF 40. Recommendations for sunscreen for oily/acne prone skin Hi, Ive been looking for a good sunscreen that is good for very oily and acne-prone skin, preferrably something lightweight since I reapply it regularly throughout the day. For that, press Windows and R keys together, type “ outlook /safe” in the opened Windows run box and click on OK. Restart the Outlook application and use Print option to print the emails now. Select the suspected Add-ins and disable them using the Disable option. Then click on Go against Manage COM Add-ins option. To locate the Add-Ins page, go to File>Options>Add-Ins. Check after which Add-In disable, the Outlook Printing problem is resolved. Checking Add-Ins: Users can check on active Add-Ins, disable them one-by-one and restart the Outlook application.
This is also valid with respect to how the annotator perceives the emotions in a text and, if the annotated data is then used to train a classifier, it can introduce a bias in the model. This is a crucial factor to take into account when classifying emotions: intuitively, the categories themselves can radically change depending on the cultural background. The cultural variation of emotions has also been studied. Russel is not the first scholar to use a circular layout to represent emotions (for instance, it was already used in ): indeed, this kind of circumplex representation became very popular over time, since it is suitable to spatially represent emotions on a continuous space. According to Russel, the full spectrum of emotions can be meaningfully placed along the resulting circumference. Russel’s model posits that affect states are defined by dimensions that are not independent: emotions can be represented as points in a space whose main orthogonal axes represent their degree of arousal and of pleasure/displeasure. One of the most famous dimensional models is Russel’s circumplex model of emotions. Such frameworks are commonly divided into categorical models, based on a finite set of labels, and dimensional models, that position data points as continuous values in an N-dimensional vector space of emotions. Sentences, conversations, posts, tweets and many other pieces of text can be labelled according to a variety of schemes, that refer to as many psychological theoretical frameworks. The recent availability of massive textual corpora has enhanced an extensive research over the emotional dimension underlying human-produced texts. We substantiate our claim that PyPlutchik outperforms other classic visualisations when displaying Plutchik emotions and we showcase a few examples that display our module’s most compelling features. Notably, PyPlutchik allows users to display also primary, secondary, tertiary and opposite dyads in a compact, intuitive way. ![]() PyPlutchik draws the Plutchik’s flower with each emotion petal sized after how much that emotion is detected or annotated in the corpus, also representing three degrees of intensity for each of them. For any enquiry about usage or installation feel free to contact the corresponding author, a Python module specifically designed for the visualisation of Plutchik’s emotions in texts or in corpora. We introduce PyPlutchik the Pyplutchik package is available as a Github repository ( ) or through the installation commands pip or conda. The most common layouts fail to preserve both features, not to mention the need of visually allowing comparisons between different corpora in a blink of an eye, that is hard with basic design solutions. The classic representation of the Plutchik’s wheel follows the principles of proximity and opposition between pairs of emotions: spatial proximity in this model is also a semantic proximity, as adjacent emotions elicit a complex emotion (a primary dyad) when triggered together spatial opposition is a semantic opposition as well, as positive emotions are opposite to negative emotions. ![]() Visualisation of such emotions is traditionally carried out using the most popular layouts, as bar plots or tables, which are however sub-optimal. ![]() Related researches range from annotation tasks description to emotions detection tools. The increasing availability of textual corpora and data fetched from social networks is fuelling a huge production of works based on the model proposed by psychologist Robert Plutchik, often referred simply as the “Plutchik Wheel”. ![]() After removing the program, some of its related processes still run on the computer.The program is not listed in the Windows Settings or Control Panel.The program is regarded by the user and/or some websites as a potentially malicious.The program is being re-installed (uninstalled and installed again afterwards).The program is not as good as the user expected.The program crashes or hangs periodically/frequently.The program is not compatible with other installed applications.These are the main reasons why Digital Clock is uninstalled by users: Some experience issues during uninstallation, whereas other encounter problems after the program is removed. It seems that there are many users who have difficulty uninstalling programs like Digital Clock from their systems. What usually makes people to uninstall Digital Clock Just follow the simple instructions, and you will uninstall the program in no time. If you are looking for an effective way to uninstall Digital Clock this guide will help you to accomplish that! Still, since it’s completely free and won’t burden your RAM in any way, there’s no reason not to have it if you want a time tracking tool on your desktop.Digital Clock is a gadget that lets you find out the current time directly from your desktop, along with other details.ĭo you have problems when you try to remove Digital Clock from your PC? Once you find that right spot, you can pin it in that position so you won’t move it by accident, and you can make it “Always on top” so that it’s easier to use with other software.ĭesktop Digital Clock can become your unobtrusive friend given time (pun probably not intended). Once the aesthetic part has been taken care of, you just get a useful clock that you can move around your screen to wherever you need it most. The clock comes with a series of predefined themes, and they all insist on taking you to gradient wonderland, but you can bypass that by selecting more down to earth colors, and by removing the Text Outline. You can change the size of the text, the transparency, or even the font (Comic Sans fans, rejoice!). Thankfully, you can start playing with the looks of your clock right away. To put it simply, WordArt was not pretty, and neither will Desktop Digital Clock be when it first appears on your screen. WordArt was a tool in some older versions of Microsoft Word which would let your write titles in the most colorful, over-the-top and cringeworthy manner. you’ll probably want to do this right after you install Desktop Digital Clock, because as soon as the application starts, you’ll be hit by flashbacks of your WordArt-filled essays from 5th grade.įor those of you that are too young to catch that reference (or for those that have repressed the memory too deep into the abyss of your subconscious). The big advantage is that you can completely customize the way this simple text is displayed, and then move it anywhere on your desktop. It will show you the exact time and date, via a small widget on your desktop. A simple digital clock for Windowsĭigital Desktop Clock doesn’t offer much, and this very simplicity is its strength. If you find yourself in any of the aforementioned categories, then you could give Digital Desktop Clock a try. ![]() Then there are those who just don’t like the standard Windows clock and would rather have a cooler widget on their desktops. These are people who need advanced time tracking in their daily activities, where every minute and every second count. But for some, even a gesture as small as this can be… well… time-consuming. These days, timekeeping can be as easy as looking at the right corner of your Windows screen. They taste great when shredded and made into a Brussels slaw. They are cruciferous vegetables that are members of the Brassica family, along with kale, cabbage, turnips, collards, broccoli and cauliflower.īrussels sprouts are wonderful roasted or sautéed, like in my Sautéed Brussels Sprouts with Maple and Rosemary, but are also fine when eaten raw. Brussels sprouts are not actually baby cabbages, contrary to popular belief. I enjoy using this variety in my Keto Lo Mein with Low Carb Asian Noodles. Bok choy is often used in Asian cooking, in stir frys, but is also delicious when cooked whole. It looks similar to mustard greens, and has a slight mustard-like flavor. Bok choy is a long variety, with leaves growing from a central stalk. ![]() It has a mild flavor and is also a popular variety used in kimchi.
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